Dividing of the standard set of amino acids into groups according to their evolutionary age

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Аннотация

It is generally accepted that the existing set of proteinogenic amino acids encoded by the standard genetic code was formed step by step in the course of evolution. Most studies name Ala, Asp, Glu, Gly, Ile, Leu, Pro, Ser, Thr and Val as early amino acids, presumably of extraterrestrial origin. However, other studies have chosen a consensus list of early amino acids in which Ile is replaced by Arg. We compared the differences between early and late amino acids for the lists with Ile and with Arg based on their physicochemical properties (AAindex database). The point-biserial correlation coefficient rpb, Student’s t-test and its reliability, p-value, were calculated between the binary lists with Ile and Arg and each AA index. Since a total of 2×553 p-values were obtained, the problem of multiple comparisons was solved using the Bonferroni correction and the Benjamini-Hochberg method. Next, we used the 2B-PLS method, which is applied to two different sets of variables related to the same objects, to find information common to both sets. The first set was the binary lists of Trifonov (Arg) and Wong (Ile), and the second set was 553 AA indexes. The maximum correlation with both the list with Ile and with Arg (1.0 and 0.8, respectively) was demonstrated by the binary AA index CHAM830108, which characterizes the ability of an amino acid to be a charge donor: late amino acids are capable of being donors, while early ones are not. Apparently, this is due to the differences in the conditions under which the standard set of amino acids evolved: prebiotic and biotic. The results of the 2B-PLS analysis also show that in the list of 10 evolutionarily early amino acids, Ile looks preferable to Arg. The allocation of the last 6 amino acids (Cys, His, Met, Phe, Trp, Tyr) obtained on the basis of the reduction of the HOMO-LUMO gap in a separate, third stage of the evolution of the set of standard amino acids is confirmed. A compact arrangement on the 2B-PLS plane of the physicochemical properties of three groups of amino acids, in which adenine, thymine and cytosine are located in the second position of the codons, respectively, as well as the maximum dispersion of amino acids with guanine in the second position of the codons, is revealed.

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Авторлар туралы

V. Efimov

Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences; Institute of Animal Systematics and Ecology, Siberian Branch, Russian Academy of Sciences; Novosibirsk State University; Tomsk State University

Хат алмасуға жауапты Автор.
Email: vmefimov@gmail.com
Ресей, Novosibirsk; Novosibirsk; Novosibirsk; Tomsk

K. Efimov

Higher School of Economics

Email: vmefimov@gmail.com
Ресей, Moscow

V. Kovaleva

Institute of Animal Systematics and Ecology, Siberian Branch, Russian Academy of Sciences

Email: vmefimov@gmail.com
Ресей, Novosibirsk

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2. Fig. 1. Configuration of amino acids on the plane of the first two bicomponents of the block of physicochemical properties. The divisions into early and late amino acids are shown: according to Wong [11] (a); according to Trifonov [2] (b); according to the HOMO-LUMO gap [6] (c) and the classification of amino acids by the second position of codons (d).

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