Hybrid antimicrobial coating based on conjugate of hyaluronic acid with peptide LL-37 for PEO-modified titanium implants

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Resumo

A conjugate of hyaluronic acid and antimicrobial peptide LL-37 was synthesized for the first time. The hybrid compound was tested as an antimicrobial organic coating for titanium samples with an inorganic sublayer obtained by plasma electrolytic oxidation (PEO) of the surface. As a result of in vitro studies, the antibacterial effect of the hybrid molecule within the inorganic PEO coating was established, which consists of a significant (p < 0.05) suppression of the ability of Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecium and Escherichia coli to form biofilms. The presented approach can be utilized for the subsequent design and development of non-fouling antimicrobial coatings to decrease the risk of infectious diseases caused by bacteria when using implants.

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Sobre autores

L. Parfenova

Institute of Petrochemistry and Catalysis of Russian Academy of Sciences

Autor responsável pela correspondência
Email: luda_parfenova@ipc-ras.ru
Rússia, 450075, Ufa, prosp. Oktyabrya, 141

Z. Galimshina

Institute of Petrochemistry and Catalysis of Russian Academy of Sciences

Email: luda_parfenova@ipc-ras.ru
Rússia, 450075, Ufa, prosp. Oktyabrya, 141

G. Gil’fanova

Institute of Petrochemistry and Catalysis of Russian Academy of Sciences

Email: luda_parfenova@ipc-ras.ru
Rússia, 450075, Ufa, prosp. Oktyabrya, 141

E. Alibaeva

Institute of Petrochemistry and Catalysis of Russian Academy of Sciences

Email: luda_parfenova@ipc-ras.ru
Rússia, 450075, Ufa, prosp. Oktyabrya, 141

T. Pashkova

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Email: luda_parfenova@ipc-ras.ru
Rússia, 460000, Orenburg, ul. Pionerskaya, 11

O. Kartashova

Institute of Cellular and Intracellular Symbiosis, Ural Branch of the Russian Academy of Sciences

Email: luda_parfenova@ipc-ras.ru
Rússia, 460000, Orenburg, ul. Pionerskaya, 11

R. Farrakhov

Ufa University of Science and Technology

Email: luda_parfenova@ipc-ras.ru
Rússia, 450076, Ufa, ul. Zaki Validi, 32

V. Aubakirova

Ufa University of Science and Technology

Email: luda_parfenova@ipc-ras.ru
Rússia, 450076, Ufa, ul. Zaki Validi, 32

E. Parfenov

Ufa University of Science and Technology

Email: luda_parfenova@ipc-ras.ru
Rússia, 450076, Ufa, ul. Zaki Validi, 32

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2. Scheme 1. Synthesis of a hybrid molecule (V) based on hyaluronic acid and antimicrobial peptide LL-37: i – EDC, H2O, pH 4.75, 18-20 °C, 2 h; ii – DTT, H2O, pH 7→8.5, 18-20°C, 24 h; iii – acetone–H2O, pH 7, 18-20°C, 2 h; iv– GC-SH (III), H2O, pH 4.75→7, 36-38°C, 2 h.

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3. Fig. 1. 1H-NMR spectra of compounds (III–V) and antimicrobial peptide LL-37 in D2O: (a) – hybrid molecule HA–LL-37 (V); (b) – HA-SH (III) (DS = 15%); (c) – conjugate EMCS–LL-37 (IV); (g) – peptide LL-37.

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