Method for Synthesis of (±)-Entecavir

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详细

Starting from (±)-lactonediol Corey, a practical route for the synthesis of (±)-Entecavir was developed, the key step of which is the preparation of (1R*,3R*,4S*)-4-(1-ethoxyethoxy)-3-[(1-ethoxyethoxy) methyl]-2-methylenecyclopentanol by oxidative decarboxylation of {(1S*,2R*,3S*,5R*)-5-{[tert-butyl(dimethyl)silyl]oxy}-3-(1-ethoxyethoxy)-2-[(1-ethoxyethoxy)methyl]cyclopentyl}acetic acid with lead tetraacetate.

作者简介

Z. Valiullina

Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences (UFRC RAS)

Email: valiullina.zulya@mail.ru
prosp. Oktyabrya, 69, Ufa, 450054 Russia

N. Ivanova

Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences (UFRC RAS)

prosp. Oktyabrya, 69, Ufa, 450054 Russia

M. Miftakhov

Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences (UFRC RAS)

prosp. Oktyabrya, 69, Ufa, 450054 Russia

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