Experimental evaluation of hepatoprotective activity of a new composition of oximethuracil with carbonic acids

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Abstract

Introduction. The high frequency of chemical poisoning is accompanied by an increase in the absolute number of cases of chemical damage to the liver. There is growing evidence that acute chemical poisoning in Russia is among the leading non-infectious diseases leading to premature death of male and female working-age people. It seems relevant to search for new pharmacological agents with low toxicity and high hepatoprotective activity, which increase the body’s stability under the influence of adverse environmental factors. The use of metabolic action drugs combining antioxidant and antihypoxic activity as hepatoprotectors is promising. The purpose of this study is an experimental evaluation of the hepatoprotective activity of a new composition of oxymethyluracil with succinic and fumaric acids.

Material and methods. The composition of 5-hydroxy-6-methyluracil with succinic and fumaric acids was first synthesized at the Ufa Institute of Chemistry. Using the model of acute liver toxic damage with carbon tetrachloride in laboratory animals, the prophylactic effect of a new drug was studied in comparison with heptor (ademetionine). Biochemical and morphological studies of laboratory animals’ biomaterial were conducted.

Results. The analysis showed that when using the studied drugs, biochemical parameters were close to the level of control animals. Morphological changes in the liver were less pronounced in the group of animals treated with the new composition, compared with changes in the structure of the liver of animals treated with heptorator (ademetionin).

Conclusion. The new composition of 5-hydroxy-6-methyluracil with succinic and fumaric acids has a protective effect on the liver of laboratory animals with the acute toxic effects of carbon tetrachloride, comparable, and in some cases, exceeding the preventive effect of heptoperam (ademetionine).

About the authors

Elvira F. Repina

Ufa Research Institute of Occupational Health and Human Ecology

Author for correspondence.
Email: noemail@neicon.ru
ORCID iD: 0000-0001-8798-0846

MD, Ph.D., senior researcher of the department of toxicology and genetics with an experimental clinic of laboratory animals Ufa Research Institute of Occupational Health and Human Ecology.

e-mail: e.f.repina@bk.ru

Russian Federation

D. O. Karimov

Ufa Research Institute of Occupational Health and Human Ecology

Email: noemail@neicon.ru
ORCID iD: 0000-0003-0039-6757
Russian Federation

G. V. Timasheva

Ufa Research Institute of Occupational Health and Human Ecology

Email: noemail@neicon.ru
ORCID iD: 0000-0003-2435-6936
Russian Federation

N. Yu. Khusnutdinova

Ufa Research Institute of Occupational Health and Human Ecology

Email: noemail@neicon.ru
ORCID iD: 0000-0001-5596-8180
Russian Federation

A. R. Gimadieva

Ufa Institute of Chemistry, RAS

Email: noemail@neicon.ru
ORCID iD: 0000-0002-2995-310X
Russian Federation

L. A. Musina

All-Russian Center for Eye and Plastic Surgery of the Russian Health Ministry

Email: noemail@neicon.ru
ORCID iD: 0000-0003-1237-9284
Russian Federation

G. F. Mukhammadieva

Ufa Research Institute of Occupational Health and Human Ecology

Email: noemail@neicon.ru
ORCID iD: 0000-0002-7456-4787
Russian Federation

S. S. Baygildin

Ufa Research Institute of Occupational Health and Human Ecology

Email: noemail@neicon.ru
ORCID iD: 0000-0002-1856-3173
Russian Federation

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