The shorten life expectancy in workers in relation to different histological types of lung cancer and absorbed dose to lungs from Plutonium-239

Cover Page

Cite item

Full Text

Abstract

The assessment of the effect of incorporated Plutonium-239 on the life expectancy in Mayak PA employees was executed on the basis of the analysis of the mortality rate and the age of death in relation to different histological types of lung cancer as lungs is one of the main organs of deposition of the nuclide. 2321 male workers of Mayak PA employed in 1948-1958 (1709 deceased and 612 alive) were included in the analysis. For different histological types, the values of the decline of life expectancy (proportion of workers that failed to attain the age of 65 years and potential years of life lost) in Mayak PA workers that had died from lung cancer were assessed in relation to incorporated Plutonium-239. As a result of the study of the reduction in the life expectancy, the increase in the number of workers that failed to attain the age of 65 years and the gain in potential years of life lost in Mayak PA workers that had died from lung cancer with absorbed dose to lungs from Plutonium-239 exceeding 1cGy was observed in relation to all the known histological types of lung cancer such as adenocarcinoma, squamous cell carcinoma and other epithelial neoplasms. However, according to the relative risk for changes observed, these effects were three times more clearly marked in the case of adenocarcinoma in comparison to other histological types of lung cancer. Such significant decline in the life expectancy in the case of adenocarcinoma was detected by both the increased mortality rate and a larger amount of untimely deaths i.e. the decreased age of the death. The comprising of life expectancy in the case of squamous cell carcinoma was less significant and was mostly detected relying upon the increased mortality rate and non-reliable trend for untimely deaths. In relation to other types of epithelial cancer, the decline in life expectancy was approximately the same as in the case of squamous cell carcinoma, though in contrast to the latter it was determined due to the increased mortality rate only. The results obtained lay the foundation for the basis for, in the first place, the comparative quantitative assessment of the contribution of increased mortality and untimely death rate to the decline in life expectancy in relation to different histological lung cancer types among Mayak PA workers, and, in the second place, for evaluation of health damage based on person-years of life lost.

About the authors

Vitaly I. Telnov

Southern Urals Biophysics Institute

Author for correspondence.
Email: tvi@subi.su

MD, Ph.D., Deputy Director of the Southern Urals Biophysics Institute, Ozyorsk, 456780, Russian Federation.

e-mail: tvi@subi.su

Russian Federation

F. D. Tretyakov

Southern Urals Biophysics Institute

Email: noemail@neicon.ru
Russian Federation

P. V. Okatenko

Southern Urals Biophysics Institute

Email: noemail@neicon.ru
Russian Federation

References

  1. Tirmarche M., Harrison J.D., Laurier D., Paquet, F., Blanchardon E., Marsh J.W. Lung cancer risk from radon and progeny and statement on radon: ICRP Publication 115. Annю ICRP. 2010; 40(1): 1-64.
  2. Il’in L.A., ed. Plutonium. Radiation Safety [Plutoniy. Radiatsionnaya bezopasnost’]. Moscow: AT; 2005. (in Russian)
  3. Cameron J.R. Longevity is the most appropriate measure of health effects of radiation. Radiology. 2003; 209(1): 14-5.
  4. Cologne J.B, Preston D.L. Longevity of atomic–bomb survivors. Lancet. 2000; 356(9226): 303-11.
  5. Tel’nov V.I. Plutonium and lifetime decrease among professional workers. Gigiena i sanitariya. 2015; 94(3): 56-60. (in Russian)
  6. Tel’nov V.I. Mortality and lifetime dynamics in the population of the Ural federal district and of the Russian Federation (2005-2014). In: Dynamics and inertia of population reproduction and replacement of generations in Russia and the CIS: VII Ural demographic forum with international participation. Sociology and history of reproduction of the population of Russia. Volume 1 [Dinamika i inertsionnost’ vosproizvodstva naseleniya i zameshcheniya pokoleniy v Rossii i SNG: VII Ural’skiy demograficheskiy forum s mezhdunarodnym uchastiem. Sotsiologiya i istoriya vosproizvodstva naseleniya Rossii. Tom 1]. Ekaterinburg; 2016: 39-45. (in Russian)
  7. Tokarskaya Z.B., Okladnikova N.D., Belyaeva Z.D., Aristov V.P. Effects of radiation and non-radiation factors on development of different histological types of lung cancer in the workers of the radiochemical facility. Voprosy onkologii. 1996; 42(1): 43-8. (in Russian)
  8. Labutina E.V., Kuznetsova I.S., Hunter N., Harrison J., Koshurnikova N.A. Radiation risk of malignant neoplasms in organs of main deposition for plutonium in the cohort of Mayak workers with regard to histological types. Health Physics. 2013; 105(2): 165-76.
  9. Koshurnikova N.A., Sokol’nikov M.E., Fomin E.P. Excess relative risk of lung cancer incidence in relation to histological type of the tumor. Voprosy radiatsionnoy bezopasnosti. 2014; (4): 62-9. (in Russian)
  10. Koshurnikova N.A., Shil’nikova N.S., Okatenko P.V., Kreslov V.V., Bolotnikova M.G., Sokol’nikov M.E., et al. Characteristics of the Mayak PA workers’ cohort. Meditsinskaya radiologiya i radiatsionnaya bezopasnost’. 1998; 43(6): 43-57. (in Russian).
  11. Vasilenko E.K. External exposure dosimetry for Mayak PA workers: instruments, methods, results. In: Kiselev M.F., Romanov S.A., eds. Radioactive Sources and Radiation Exposure Effects on the Mayak PA Workers and Population Living in the Area of Nuclear Facility Influence. Part 1 [Istochniki i effekty oblucheniya rabotnikov PO «Mayak» i naseleniya prozhivayushchego v zone vliyaniya predpriyatiya. Chast’ 1]. Chelyabinsk: Chelyabinskiy dom pechati; 2009: 51-100. (in Russian)
  12. Khokhryakov V.V., Khokhryakov V.F., Suslova K.G., Vostrotin V.V., Vvedensky V.E., Sokolova A.B., et al. Mayak Worker Dosimetry System 2008 (MWDS-2008): Assessment of internal dose from measurement results of plutonium activity in urine. Health Phys. 2013; 104(4): 366-78.
  13. Glantz S.A. Primer of Biostatistics. New-York: McGraw-Hill; 1994.
  14. Deltour I., Tretyakov F., Tsareva Yu., Azizova T., Schüz J. Mortality of populations potentially exposed to ionising radiation, 1953-2010, in the closed city of Ozyorsk, Southern Urals: a descriptive study. Environ. Health. 2015; 14(1): 91-102.
  15. Preston D.L., Ron E., Tokuoka S., Funamoto S., Nishi N., Soda M., et al. Solid cancer incidence in atomic bomb survivors: 1958–1998. Radiat. Res. 2007; 168(1): 1-64.
  16. Fleis J. Statistical Methods for Rates and Proportions. New York-Singapore: John Wiley & Sons; 1973.
  17. Gubler E.V. Computational Methods of Analysis and Identification of Pathologic Processes [Vychislitel’nye metody analiza i raspoznavaniya patologicheskikh protsessov]. Leningrad: Meditsina; 1978. (in Russian)
  18. Khalafyan A.A. STATISTICA 6. Statistic Data Analysis [STATISTICA 6. Statisticheskiy analiz dannykh]. Moscow: Binom-Press; 2010. (in Russian)
  19. Sokol’nikov M.E., Vostrotin V.V., Efimov A.V., Vasilenko E.K., Romanov S.A. Lifelong risk of lung cancer mortality as a measure of reliability of radiation safety standard regarding exposure to alpha-radiation from inhaled plutonium-239. Radiatsiya i risk. 2015; 24(3): 59-70. (in Russian)
  20. Bykov A.A. Methodology of economical assessment of an average person’s life (explanatory note). Problemy analiza riska. 2007; 4(2): 178-91. (in Russian)

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2024 Telnov V.I., Tretyakov F.D., Okatenko P.V.


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 37884 от 02.10.2009.