On the role of the thioldisulphyde system in protection the human body from aerosol air pollution

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Abstract

In this paper results of research of quantitative distribution and qualitative characteristics of microdispersed particles of atmospheric air in the city of Vladivostok are presented. The chronic impact of aerosols of a microsize range on inhabitants of the urbanized territory led to the development of a condition of an oxidative stress giving rise in the increase of the level of oxidative damages of cellular macromolecules and the expansion in the number of cells with the lowered power status in comparison with residents of the favorable area. The induction of oxidative processes caused the enlargement in the content of key antioxidant enzymes (thireodoxin, glutathione, superoxide dismutase) and the gain of antioxidant activity in general. The main role in reparation of proteins and DNA in the oxidizing influence of microdispersed particles belongs to thioredoxin system due to restoration of thiol-disulfide communications and restoration of reparating enzymes. Thiol-disulfide-depended antioxidant processes make an essential contribution to the protection of an organism, preventing the development of the oxidative stress and the cell apoptosis. Long-term stress - induced influence of microdispersed particles can lead to exhaustion of adaptation and reparation opportunities of an organism and to promote еру development of pathology.

About the authors

Tatyana I. Vitkina

Vladivostok branch of the Far Eastern scientific center of physiology and pathology of breathing-Research Institute of Medical Climatology and Rehabilitation

Author for correspondence.
Email: tash30@mail.ru
ORCID iD: 0000-0002-1009-9011

MD, PhD, DSci., Professor of RAS, Head of the Laboratory of Medical Ecology and Recreational Resources of the  Far Eastern Scientific Center of Physiology and Pathology of Breathing, of the Vladivostok branch of the Far Eastern scientific center of physiology and pathology of breathing — Research Institute of Medical Climatology and Rehabilitation, Vladivostok, 690105, Russian Federation.

e-mail: tash30@mail.ru

Russian Federation

T. A. Gvozdenko

Vladivostok branch of the Far Eastern scientific center of physiology and pathology of breathing-Research Institute of Medical Climatology and Rehabilitation

Email: noemail@neicon.ru
ORCID iD: 0000-0002-6413-9840
Russian Federation

V. N. Rakitskiy

F.F. Erisman Federal Center of Hygiene

Email: noemail@neicon.ru
Russian Federation

V. P. Kolosov

Far Eastern Scientific Center of Physiology and Pathology of Breathing

Email: noemail@neicon.ru
ORCID iD: 0000-0002-8854-4752
Russian Federation

V. I. Yankova

Vladivostok branch of the Far Eastern scientific center of physiology and pathology of breathing-Research Institute of Medical Climatology and Rehabilitation

Email: noemail@neicon.ru
ORCID iD: 0000-0002-7310-2599
Russian Federation

A. Yu. Gorkavaya

Vladivostok branch of the Far Eastern scientific center of physiology and pathology of breathing-Research Institute of Medical Climatology and Rehabilitation

Email: noemail@neicon.ru
Russian Federation

A. V. Nazarenko

Vladivostok branch of the Far Eastern scientific center of physiology and pathology of breathing-Research Institute of Medical Climatology and Rehabilitation

Email: noemail@neicon.ru
Russian Federation

V. V. Chayka

Far Eastern Federal University

Email: noemail@neicon.ru
Russian Federation

V. V. Kodintsev

Far Eastern Federal University

Email: noemail@neicon.ru
Russian Federation

P. F. Kiku

Far Eastern Federal University

Email: noemail@neicon.ru
Russian Federation

K. S. Golokhvast

Vladivostok branch of the Far Eastern scientific center of physiology and pathology of breathing-Research Institute of Medical Climatology and Rehabilitation; Far Eastern Federal University

Email: noemail@neicon.ru
ORCID iD: 0000-0002-4873-2281
Russian Federation

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Copyright (c) 2024 Vitkina T.I., Gvozdenko T.A., Rakitskiy V.N., Kolosov V.P., Yankova V.I., Gorkavaya A.Y., Nazarenko A.V., Chayka V.V., Kodintsev V.V., Kiku P.F., Golokhvast K.S.


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