The combined effect of behavioural and occupational risk factors on the formation of bronchopulmonary pathology in agricultural workers (literature review)

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Abstract

Occupational activities in agricultural workers involve exposure to several harmful environmental and occupational factors potent of affecting workers’ health. In addition to that, low adherence to healthy lifestyles was revealed among agricultural workers. Combined effects produced by behavioural and occupational risk factors can induce pathogenetic mechanisms of occupational, work-related and general somatic diseases, included bronchopulmonary pathology.

To obtain necessary information, a search was performed for relevant studies published in the abstract databases Scopus, Web of Science, PubMed, RSCI for the period of 2000–2024 by keywords. The review includes data from sixty five full-text sources.

Anti-inflammatory effects of alcohol on dust inhalation did not lead to a decrease in adverse impact of the dust factor but instead was accompanied by an increased risk of inflammatory processes in the respiratory organs. The combined contribution made by the dust factor and smoking to development of respiratory pathology remains poorly understood. Workers are affected by a number of factors leading to abdominal obesity, which is a risk factor for the development of bronchopulmonary pathology. Chronic stress, which is typical for agricultural workers, is a risk factor potent of causing diseases of the respiratory system, both by independently triggering pathogenetic mechanisms of disease development and acting indirectly through the formation of metabolic disorders.

Conclusion. Agricultural workers are exposed to harmful occupational factors (inorganic dust, organic dust, and pesticides) as well as to relevant behavioural factors (alcohol, smoking, poor nutrition, and psychological stress), which have an adverse effect on the respiratory system. It is necessary to further study the combined influence of behavioural and occupational risk factors on the development of bronchopulmonary pathology in agricultural workers.

Contribution:
Raikova S.V. – the study concept and design, data collection and analysis, writing the text;
Mazilov S.I. – data collection and analysis, statistical analysis;
Komleva N.E. – editing the text;
Zaikina I.V. – data collection and analysis.
All authors have approved the final version of the manuscript and bear full responsibility for the integrity of all its parts.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: August 13, 2024 / Accepted: November 19, 2024 / Published: December 17, 2024

About the authors

Svetlana V. Raikova

Saratov Hygiene Medical Research Center of the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Email: matiz853@yandex.ru

PhD (Medicine), Assistant Professor, Senior Researcher, Department of Medical-Preventive and Innovative Technologies, Saratov Hygiene Medical Research Center Saratov, 410022, Russian Federation

e-mail: matiz853@yandex.ru

Svyatoslav I. Mazilov

Saratov Hygiene Medical Research Center of the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Email: smazilov@ya.ru

PhD (Biology), Researcher, Department of Medical-Preventive and Innovative Technologies, Saratov Hygiene Medical Research, Saratov, 410022, Russian Federation

e-mail: smazilov@ya.ru

Nataliia E. Komleva

Saratov Hygiene Medical Research Center of the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Email: nekomleva@yandex.ru

DSc (Medicine), Deputy Chief of Science, Saratov Hygiene Medical Research Center, Saratov, 410022, Russian Federation

e-mail: nekomleva@yandex.ru

Inna V. Zaikina

Saratov Hygiene Medical Research Center of the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Author for correspondence.
Email: innaza2@mail.ru

PhD (Medicine), Senior Researcher, Department of Medical-Preventive and Innovative Technologies, Saratov Hygiene Medical Research Center, Saratov, 410022, Russian Federation

e-mail: innaza2@mail.ru

References

  1. Onishchenko G.G., Rakitskiy V.N., Sinoda V.A., Trukhina G.M., Lutsenko L.A., Sukhova A.V. The health maintenance of workers under implementation of health- and resource-saving technology. Zdravookhranenie Rossiiskoi Federatsii. 2015; 59(6): 4–8. https://elibrary.ru/uxlsph (in Russian)
  2. Popova A.Yu. Issues and trends in occupational morbidity of agricultural workers of the Russian Federation. Zdorov’e naseleniya i sreda obitaniya – ZNISO. 2016; (9): 4–9. https://elibrary.ru/wmdift (in Russian)
  3. Stoleski S., Minov J., Mijakoski D., Karadzinska-Bislimovska J. Chronic respiratory symptoms and lung function in agricultural workers – influence of exposure duration and smoking. Open Access Maced. J. Med. Sci. 2015; 3(1): 158–65. https://doi.org/10.3889/oamjms.2015.014
  4. Bezrukova G.A., Shalashova M.L., Novikova T.A., Spirin V.F. The influence of working conditions in basic livestock sectors on the nosological structure of occupational morbidity among workers. Sanitarnyi vrach. 2020; (3): 38–47. https://doi.org/10.33920/med-08-2003-04 https://elibrary.ru/dwovdw (in Russian)
  5. Schenker M.B. Inorganic agricultural dust exposure causes pneumoconiosis among farmworkers. Proc. Am. Thorac. Soc. 2010; 7(2): 107–10. https://doi.org/10.1513/pats.200906-036RM
  6. Shabrova E.S., Shkrabak R.V., Vedeneeva A.A., Kosyrev P.I., Shkrabak V.S., Ivanov A.A. Analysis of the main causes of occupational morbidity among livestock workers. Agrarnyi nauchnyi zhurnal. 2021; (12): 130–4. https://doi.org/10.28983/asj.y2021i12pp130-134 https://elibrary.ru/rgkmiz (in Russian)
  7. Von Essen S.G., Auvermann B.W. Health effects from breathing air near CAFOs for feeder cattle or hogs. J. Agromedicine. 2005; 10(4): 55–64. https://doi.org/10.1300/J096v10n04_08
  8. Mathisen T., Von Essen S.G., Wyatt T.A., Romberger D.J. Hog barn dust extract augments lymphocyte adhesion to human airway epithelial cells. J. Appl. Physiol. 2004; 96(5): 1738–44. https://doi.org/10.1152/japplphysiol.00384.2003
  9. Donham K.J., Cumro D., Reynolds S.J., Merchant J.A. Dose-response relationships between occupational aerosol exposures and cross-shift declines of lung function in poultry workers: recommendations for exposure limits. J. Occup. Environ. Med. 2000; 42(3): 260–9. https://doi.org/10.1097/00043764-200003000-00006.
  10. Curl C.L., Spivak M., Phinney R., Montrose L. Synthetic pesticides and health in vulnerable populations: agricultural workers. Curr. Environ. Health Rep. 2020; 7(1): 13–29. https://doi.org/10.1007/s40572-020-00266-5
  11. Mikerov A.N., Bezrukova G.A., Novikova T.A. Occupational non-communicable respiratory diseases in industrial and agricultural workers. Gigiena i Sanitaria (Hygiene and Sanitation, Russian journal). 2023; 102(10): 1056–62. https://doi.org/10.47470/0016-9900-2023-102-10-1056-1062 https://elibrary.ru/kobabk (in Russian)
  12. Krekoten O.M., Dereziuk A.V., Ihnaschuk O.V., Holovchanska S.E. Analysis of major risk factors affecting those working in the agrarian sector (based on a sociological survey). Wiad. Lek. 2017; 70(5): 925–9.
  13. Watanabe-Galloway S., Chasek C., Yoder A.M., Bell J.E. Substance use disorders in the farming population: Scoping review. J. Rural Health. 2022; 38(1): 129–50. https://doi.org/10.1111/jrh.12575
  14. Vyalshina A.A. Prevalence of smoking and alcohol consumption among rural population in Russia. Sotsial’nye aspekty zdorov’ya naseleniya. 2021; 67(5): 8. https://doi.org/10.21045/2071-5021-2021-67-5-8 https://elibrary.ru/fqfqec (in Russian)
  15. Sisson J.H. Alcohol and airways function in health and disease. Alcohol. 2007; 41(5): 293–307. https://doi.org/10.1016/j.alcohol.2007.06.003
  16. Brown L.A., Harris F.L., Ping X.D., Gauthier T.W. Chronic ethanol ingestion and the risk of acute lung injury: A role for glutathione availability? Alcohol. 2004; 33(3): 191–7. https://doi.org/10.1016/j.alcohol.2004.08.002
  17. Molina P.E., Happel K.I., Zhang P., Kolls J.K., Nelson S. Focus on: Alcohol and the immune system. Alcohol. Res. Health. 2010; 33(1-2): 97–108.
  18. Joshi P.C., Guidot D.M. The alcoholic lung: Epidemiology, pathophysiology, and potential therapies. Am. J. Physiol. Lung Cell. Mol. Physiol. 2007; 292(4): L813–23. https://doi.org/10.1152/ajplung.00348.2006
  19. Gerald C.L., Romberger D.J., DeVasure J.M., Khazanchi R., Nordgren T.M., Heires A.J., et al. Alcohol decreases organic dust-stimulated airway epithelial TNF-alpha through a nitric oxide and protein kinase-mediated inhibition of TACE. Alcohol. Clin. Exp. Res. 2016; 40(2): 273–83. https://doi.org/10.1111/acer.12967
  20. McCaskill M.L., Romberger D.J., DeVasure J., Boten J., Sisson J.H., Bailey K.L., et al. Alcohol exposure alters mouse lung inflammation in response to inhaled dust. Nutrients. 2012; 4(7): 695–710. https://doi.org/10.3390/nu4070695
  21. Wyatt T.A., Canady K., Heires A.J., Poole, J.A., Bailey K.L., Nordgren T.M., et al. Alcohol inhibits organic dust-induced ICAM-1 expression on bronchial epithelial cells. Safety. 2017; 3(1): 5. https://doi.org/10.3390/safety3010005
  22. Happel K.I., Nelson S. Alcohol, immunosuppression, and the lung. Proc. Am. Thorac. Soc. 2005; 2(5): 428–32. https://doi.org/10.1513/pats.200507-065JS
  23. Mehta H., Nazzal K., Sadikot R.T. Cigarette smoking and innate immunity. Inflamm. Res. 2008; 57(11): 497–503. https://doi.org/10.1007/s00011-008-8078-6
  24. Nikiforova T.I., Ozerskaya I.V., Geppe N.A., Handy M.V., Chernogradsky A.I. Smoking and the state of the ciliary epithelium of the respiratory tract in adolescents. Rossiiskii vestnik perinatologii i pediatrii. 2020; 65(4): 94–100. https://doi.org/10.21508/1027-4065-2020-65-4-94-100 https://elibrary.ru/rfexhc (in Russian)
  25. Liu Z., Chen S., Xu Y., Liu X., Xiong P., Fu Y. Surfactant protein A expression and distribution in human lung samples from smokers with or without chronic obstructive pulmonary disease in China. Medicine (Baltimore). 2020; 99(7): e19118. https://doi.org/10.1097/MD.0000000000019118
  26. Lugg S.T., Scott A., Parekh D., Naidu B., Thickett D.R. Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease. Thorax. 2022; 77(1): 94–101. https://doi.org/10.1136/thoraxjnl-2020-216296
  27. Asfandiyarova N.S. Nicotine and immune system. Immunopatologiya, allergologiya, infektologiya. 2018; (3): 6–12. https://doi.org/10.14427/jipai.2018.3.6 https://elibrary.ru/zcywux (in Russian)
  28. Mortaz E., Lazar Z., Koenderman L., Kraneveld A.D., Nijkamp F.P., Folkerts G. Cigarette smoke attenuates the production of cytokines by human plasmacytoid dendritic cells and enhances the release of IL-8 in response to TLR-9 stimulation. Respir. Res. 2009; 10(1): 47. https://doi.org/10.1186/1465-9921-10-47
  29. Kotlyarov S.N., Suchkov I.A., Uryasyev O.M., Yakusheva E.N., Shchulkin A.V., Kotlyarova A.A. Analysis of influence of cigarette smoke on signaling pathways of innate immune system in monocytes of peripheral blood. Rossiiskii mediko-biologicheskii vestnik imeni akademika I.P. Pavlova. 2023; 31(3): 391–404. https://doi.org/10.17816/PAVLOVJ306495 https://elibrary.ru/hchjkb (in Russian)
  30. Melnikova I.M., Dorovskaya N.L., Dmitrieva A.P., Mizernitskiy Yu.L. Current medical and social aspects of tobacco and nicotine-containing products consumption in adolescents. Permskii meditsinskii zhurnal. 2022; 39(3): 90–101. https://doi.org/10.17816/pmj39390-101 https://elibrary.ru/cjwwxf (in Russian)
  31. Marescaux A., Degano B., Soumagne T., Thaon I., Laplante J.J., Dalphin J.C. Impact of farm modernity on the prevalence of chronic obstructive pulmonary disease in dairy farmers. Occup. Environ. Med. 2016; 73(2): 127–33. https://doi.org/10.1136/oemed-2014-102697
  32. Wang C., Xu J., Yang L., Xu Y., Zhang X., Bai C., et al. Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study. Lancet. 2018; 391(10131): 1706–717. https://doi.org/10.1016/S0140-6736(18)30841-9
  33. Gao Z., Dosman J.A., Rennie D.C., Schwartz D.A., Yang I.V., Beach J., et al. A. Effects of tumor necrosis factor (TNF) gene polymorphisms on the association between smoking and lung function among workers in swine operations. J. Toxicol. Environ. Health Part A. 2021; 84(13): 536–52. https://doi.org/10.1080/15287394.2021.1896404
  34. GBD 2019 Risk Factors Collaborators. Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020; 396(10258): 1223–49. https://doi.org/10.1016/S0140-6736(20)30752-2
  35. Dorner T., Leitner B., Stadlmann H., Fischer W., Neidhart B., Lawrence K., et al. Prevalence of overweight and obesity in Austrian male and female farmers. Soz. Praventivmed. 2004; 49(4): 243–6. https://doi.org/10.1007/s00038-004-3120-0
  36. Bolotova E.V., Samorodskaya I.V., Komissarova I.M. Relationship of body mass index and abdominal obesity in rural population of Krasnodarsky kray taken. Ozhirenie i metabolizm. 2016; 13(1): 25–9. https://doi.org/10.14341/omet2016125-29 https://elibrary.ru/wdhzah (in Russian)
  37. Noppakun K., Juntarawijit C. Association between pesticide exposure and obesity: A cross-sectional study of 20,295 farmers in Thailand. F1000Res. 2021; 10: 445. https://doi.org/10.12688/f1000research.53261.3
  38. Miranda R.A., Silva B.S., de Moura E.G., Lisboa P.C. Pesticides as endocrine disruptors: programming for obesity and diabetes. Endocrine. 2023; 79(3): 437–47. https://doi.org/10.1007/s12020-022-03229-y
  39. Hawes N.J., Wiggins A.T., Reed D.B., Hardin-Fanning F. Poor sleep quality is associated with obesity and depression in farmers. Public Health Nurse. 2019; 36(3): 270–5. https://doi.org/10.1111/phn.12587
  40. Komleva N.E., Zaikina I.V., Danilov A.N. Quality of life of agricultural workers with gastroesophageal reflux disease. Meditsina truda i promyshlennaya ehkologiya. 2019; 59(4): 233–6. https://doi.org/10.31089/1026-9428-2019-59-4-233-236 https://elibrary.ru/gjqpyt (in Russian)
  41. Shalnova S.A., Maksimov S.A., Balanova Yu.A., Evstifeeva S.E., Imaeva A.E., Kapustina А.V., et al. Adherence to a healthy lifestyle of the Russian population depending on the socio-demographics. Kardiovaskulyarnaya terapiya i profilaktika. 2020; 19(2): 33–41. https://doi.org/10.15829/1728-8800-2020-2452 https://elibrary.ru/zzecci (in Russian)
  42. Dixon A.E., Peters U. The effect of obesity on lung function. Expert. Rev. Respir. Med. 2018; 12(9): 755–67. https://doi.org/10.1080/17476348.2018.1506331
  43. Liu J., Xu H., Cupples L.A., O’ Connor G.T., Liu C.T. The impact of obesity on lung function measurements and respiratory disease: A Mendelian randomization study. Ann. Hum. Genet. 2023; 87(4): 174–83. https://doi.org/10.1111/ahg.12506
  44. Boykov V.A., Kobyakova O.S., Deyev I.A., Kulikov Ye.S., Starovoytova Ye.A. State of respiratory function in patients with obesity. Byulleten’ sibirskoi meditsiny. 2013; 12(1): 86–92 https://doi.org/10.20538/1682-0363-2013-1-86-92 https://elibrary.ru/qabarf (in Russian)
  45. Brock J.M., Billeter A., Müller-Stich B.P., Herth F. Obesity and the lung: what we know today. Respiration. 2020; 99(10): 856–66. https://doi.org/10.1159/000509735
  46. Kuzmina L.P., Khotuleva A.G. Metabolic syndrome in occupational respiratory diseases. Meditsina truda i promyshlennaya ehkologiya. 2018; 58(12): 8–13. https://doi.org/10.31089/1026-9428-2018-12-8-13 https://elibrary.ru/ypxltf (in Russian)
  47. Miftakhova A.M., Pestrenin L.D., Gulyaeva I.L. Role of leptin in pathogenesis of hepatic steatosis, steatohepatitis and endothelial dysfunction in obesity: literature review. Permskii meditsinskii zhurnal. 2020; 37(3): 58–65. https://doi.org/10.17816/pmj37358-65 https://elibrary.ru/oobjje (in Russian)
  48. Malli F., Papaioannou A.I., Gourgoulianis K.I., Daniil Z. The role of leptin in the respiratory system: an overview. Respir. Res. 2010; 11(1): 152. https://doi.org/10.1186/1465-9921-11-152
  49. Schulte P.A., Wagner G.R., Ostry A., Blanciforti L.A., Cutlip R.G., Krajnak K.M., et al. Work, obesity, and occupational safety and health. Am. J. Public Health. 2007; 97(3): 428–36. https://doi.org/10.2105/AJPH.2006.086900
  50. Stallones L., Doenges T., Dik B.J., Valley M.A. Occupation and suicide: Colorado, 2004–2006. Am. J. Ind. Med. 2013; 56(11): 1290–5. https://doi.org/10.1002/ajim.22228
  51. Yazd S.D., Wheeler S.A., Zuo A. Key risk factors affecting farmer’s mental health: a systematic review. Int. J. Environ. Res. Public Health. 2019; 16(23): 4849. https://doi.org/10.3390/ijerph16234849
  52. Truchot D., Andela M. Burnout and hopelessness among farmers: the farmers stressors inventory. Soc. Psychiatry Psychiatr. Epidemiol. 2018; 53(8): 859–67. https://doi.org/10.1007/s00127-018-1528-8
  53. Cancino J., Soto K., Tapia J., Muñoz-Quezada M.T., Lucero B., Contreras C., et al. Occupational exposure to pesticides and symptoms of depression in agricultural workers. A systematic review. Environ. Res. 2023; 231(2): 116190. https://doi.org/10.1016/j.envres.2023.116190
  54. Brew B., Inder K., Allen J., Thomas M., Kelly B. The health and wellbeing of Australian farmers: a longitudinal cohort study. BMC Public Health. 2016; 16(1): 988. https://doi.org/10.1186/s12889-016-3664-y
  55. Isgandarova G.N., Hatamzade E.M. Diagnosis of chronic obstructive pulmonary disease in primary health care. Permskii meditsinskii zhurnal. 2023; 40(4): 31–40. https://doi.org/10.17816/pmj40431-40 https://elibrary.ru/nzztud (in Russian)
  56. Starkova O.Ya. Peculiarities of working conditions in rural areas. Ehkonomika sel’skogo khozyaistva Rossii. 2020; (6): 105–8. https://doi.org/10.32651/206-105 https://elibrary.ru/kjxmxc (in Russian)
  57. Vodyakha S.A., Vodyakha Yu.E. Stress coping strategies and tendency to use psychoactive substances. Pedagogicheskoe obrazovanie v Rossii. 2022; (3): 171–8. https://elibrary.ru/gctdbs (in Russian)
  58. Sung E.S., Choi C.K., Jeong J.A., Shin M.H. The relationship between body mass index and poor self-rated health in the South Korean population. PLoS One. 2020; 15(8): e0219647. https://doi.org/10.1371/journal.pone.0219647
  59. Puddephatt J.A., Irizar P., Jones A., Gage S.H., Goodwin L. Associations of common mental disorder with alcohol use in the adult general population: a systematic review and meta-analysis. Addiction. 2022; 117(6): 1543–72. https://doi.org/10.1111/add.15735
  60. Garey L., Olofsson H., Garza T., Rogers A.H., Kauffman B.Y., Zvolensky M.J. Directional effects of anxiety and depressive disorders with substance use: a review of recent prospective research. Curr. Addict. Rep. 2020; 7: 344–55. https://doi.org/10.1007/s40429-020-00321-z
  61. Werchan C.A., Steele A.M., Janssens T., Millard M.W., Ritz T. Towards an assessment of perceived COPD exacerbation triggers: Initial development and validation of a questionnaire. Respirology. 2019; 24(1): 48–54. https://doi.org/10.1111/resp.13368
  62. Liccardi G., Calzetta L., Milanese M., Salzillo A., Manzi F., Ferrari M., et al. Psychological stress, lung function and exacerbation risk in COPD: Is an increase of cholinergic tone a possible link? COPD. 2018; 15(3): 310–1. https://doi.org/10.1080/15412555.2018.1459533
  63. Kham-Ai P., Heaton K., Li P. Association between COPD symptoms and psychological distress among farmers. Workplace Health Saf. 2023; 71(2): 89–95. https://doi.org/10.1177/21650799221113057
  64. Pumar M.I., Gray C.R., Walsh J.R., Yang I.A., Rolls T.A., Ward D.L. Anxiety and depression-Important psychological comorbidities of COPD. J. Thorac. Dis. 2014; 6(11): 1615–31. https://doi.org/10.3978/j.issn.2072-1439.2014.09.28
  65. Hirotsu C., Tufik S., Andersen M.L. Interactions between sleep, stress, and metabolism: from physiological to pathological conditions. Sleep Science. 2015; 8(3): 143–52. https://doi.org/10.1016/j.slsci.2015.09.002

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