Influence of ApoE gene polymorphism on development of obesity and blood biochemical parameters in coal mine workers

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅存取

详细

Introduction. The prevalence of obesity is becoming more relevant every year. Individuals with increased body weight show alterations in various biochemical parameters including lipid profile. One of the genes involved in the regulation of lipid metabolism is the APOE gene.
The aim of the work. To study the influence of ApoE gene on biochemistry parameters and BMI level in coal mine workers.
Materials and Methods. Data of one hundred thirty four coal mine workers were included. Venous blood was collected from all participants for DNA and serum isolation. Further genotyping was carried out for two polymorphic variants of ApoE gene (rs7412 and rs429358). Along with this, blood biochemical parameters were evaluated.
Results. While studying the effect of two polymorphic variants on BMI in subjects, a significant association was noted among carriers of E2/E3 and E3/E3 genotypes. Among biochemical indices, had an effect on cholesterol, folic acid, homocysteine, total calcium, low density lipoproteins, alkaline phosphatase,
γ-glutamyltransferase, and fibrinogen.
Limitations. The results obtained characterize the situation at a specific production site (coal mine) in a particular region (Russia, Western Siberia). In the future, the reproducibility of the results of our study will be tested on other, larger samples with a wide range of genetic variants related to lipid metabolism and eating behaviour.
Conclusion. The results obtained in this study may be useful for further work in the formation of certain risk groups and preventive measures.

作者简介

Anastasia Yakovleva

Kemerovo State University

Email: asya-kemerovo2012@yandex.ru
Engineer, Department of Genetics and Fundamental Medicine, Kemerovo State University, Kemerovo, 650000, Russian Federation

Varvara Minina

Kemerovo State University; Federal Research Center of Coal and Coal Chemistry, Siberian Branch of the Russian Academy of Sciences

Email: vminina@mail.ru
DSc (Biology), Head of the Department of Genetics and Fundamental Medicine, Kemerovo State University, Kemerovo, 650000, Russian Federation

Olga Soboleva

Federal Research Center of Coal and Coal Chemistry, Siberian Branch of the Russian Academy of Sciences

Email: soboleva.olga88@yandex.ru
leading processing engineer, Laboratory of Cytogenetics, Federal Research Center of Coal and Coal Chemistry, Siberian Branch of the Russian Academy of Sciences, Kemerovo, 650000, Russian Federation

Olga Borisova

Kemerovo State University

student of Kemerovo State University, Kemerovo, 650000, Russian Federation

Olga Bulatova

Kemerovo State University

Associate Professor, Department of Genetics and Fundamental Medicine, Kemerovo State University, Kemerovo, 650000, Russian Federation

Alexander Prosekov

Kemerovo State University

Email: aprosekov@rambler.ru
DSc (Engineering), Professor, Laboratory of Biocatalysis, Kemerovo State University, Kemerovo, 650000, Russian Federation

参考

  1. Тимофеев Ю.С., Джиоева О.Н., Драпкина О.М. Циркулирующие биологические маркеры ожирения: на пути к системному подходу. Кардиоваскулярная терапия и профилактика. 2014; 22(4): 85–93. https://doi.org/10.15829/1728-8800-2023-3551 https://elibrary.ru/qfortp
  2. Полянина Д.Д., Берёза И.А., Амромина А.М., Шаихова Д.Р., Астахова С.Г., Сутункова М.П. и др. Полиморфизм гена APOE как фактор риска развития ожирения работников с вредными условиями труда на предприятиях черной металлургии. Анализ риска здоровью. 2023; (2): 155–9. https://doi.org/10.21668/health.risk/2023.2.15 https://elibrary.ru/pclbmi
  3. Алфёрова В.И., Мустафина С.В. Распространенность ожирения во взрослой популяции российской федерации (обзор литературы). Ожирение и метаболизм. 2022; 19(1): 96–105. https://doi.org/10.14341/omet12809 https://elibrary.ru/ecocvf
  4. Шенкова Н.Н., Веселовская Н.Г., Чумакова Г.А., Осипова Е.С., Гриценко О.В., Отт А.В. Прогнозирование риска субклинического атеросклероза брахиоцефальных артерий у женщин с ожирением. Российский кардиологический журнал. 2017; 22(4): 54–60. https://doi.org/10.15829/1560-4071-2017-4-54-60 https://elibrary.ru/ymhtrz
  5. Филимонов Е.С., Коротенко О.Ю., Уланова Е.В. Кардиореспираторные нарушения при абдоминальном ожирении у работников угледобывающих предприятий юга Кузбасса. Медицина труда и промышленная экология. 2021; 61(3): 168–172. https://doi.org/10.31089/1026-9428-2021-61-3-168-172 https://elibrary.ru/nxczxp
  6. Klop B., Elte J.W., Cabezas M.C. Dyslipidemia in obesity: mechanisms and potential targets. Nutrients. 2013; 5(4): 1218–40. https://doi.org/10.3390/nu50412188
  7. Shatwan I.M., Winther K.H., Ellahi B., Elwood P., Ben-Shlomo Y., Givens I., et al. Association of apolipoprotein E gene polymorphisms with blood lipids and their interaction with dietary factors. Lipids Health Dis. 2018; 17(1): 98. https://doi.org/10.1186/s12944-018-0744-2
  8. Semaev S., Shakhtshneider E., Shcherbakova L., Ivanoshchuk D., Orlov P., Malyutina S., et al. Associations of APOE gene variants rs429358 and rs7412 with parameters of the blood lipid profile and the risk of myocardial infarction and death in a white population of Western Siberia. Curr. Issues Mol. Biol. 2022; 44(4): 1713–24. https://doi.org/10.3390/cimb44040118
  9. Rahman N., Zakiullah Z., Jan A., Saeed M., Khan M.A., Parveen Z., Iqbal J., et al. Association of APOE (rs429358 and rs7412) and PON1 (Q192R and L55M) variants with myocardial infarction in the pashtun ethnic population of Khyber Pakhtunkhwa, Pakistan. Genes (Basel). 2023; 14(3): 687. https://doi.org/10.3390/genes14030687
  10. Wu H., Huang Q., Yu Z., Wu H., Zhong Z. The SNPs rs429358 and rs7412 of APOE gene are association with cerebral infarction but not SNPs rs2306283 and rs4149056 of SLCO1B1 gene in southern Chinese Hakka population. Lipids Health Dis. 2020; 19(1): 202. https://doi.org/10.1186/s12944-020-01379-4
  11. Egert S., Rimbach G., Huebbe P. ApoE genotype: from geographic distribution to function and responsiveness to dietary factors. Proc. Nutr. Soc. 2012; 71(3): 410–24. https://doi.org/10.1017/S0029665112000249
  12. Li W., Liu F., Liu R., Zhou X., Li G., Xiao S. APOE E4 is associated with hyperlipidemia and obesity in elderly schizophrenic patients. Sci. Rep. 2021; 11(1): 14818. https://doi.org/10.1038/s41598-021-94381-4
  13. Иванова Т.И., Полуэктова М.В., Хорохорина В.А., Воробьёва О.А., Чиркова Т.В., Мкртчян Л.С. и др. Влияние генотипов APOE на биохимические показатели метаболизма железа и липидов у больных неопластическими заболеваниями эндометрия и здоровых женщин. Исследования и практика в медицине. 2014; 1(1): 35–44. https://elibrary.ru/touqdh
  14. Wang C., Ji X., Tang Z., Zhang Z., Gu X., Fang X. Combined homocysteine and apoE rs429358 and rs7412 polymorphism in association with serum lipid levels and cognition in Chinese community-dwelling older adults. BMC Psychiatry. 2022; 22(1): 223. https://doi.org/10.1186/s12888-022-03877-4
  15. Zhen J., Huang X., Van Halm-Lutterodt N., Dong S., Ma W., Xiao R., et al. ApoE rs429358 and rs7412 polymorphism and gender differences of serum lipid profile and cognition in aging Chinese population. Front. Aging Neurosci. 2017; 9: 248. https://doi.org/10.3389/fnagi.2017.00248
  16. Smalinskiene A., Petkeviciene J., Luksiene D., Jureniene K., Klumbiene J., Lesauskaite V. Association between APOE, SCARB1, PPARα polymorphisms and serum lipids in a population of Lithuanian adults. Lipids Health Dis. 2013; 12: 120. https://doi.org/10.1186/1476-511X-12-120
  17. Mahley R.W. Central nervous system lipoproteins: ApoE and regulation of cholesterol metabolism. Arterioscler Thromb. Vasc. Biol. 2016; 36(7): 1305–15. https://doi.org/10.1161/ATVBAHA.116.307023
  18. Gustavsson J., Mehlig K., Leander K., Strandhagen E., Björck L., Thelle D.S., et al. Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women. Atherosclerosis. 2012; 220(2): 486–92. https://doi.org/10.1016/j.atherosclerosis.2011.10.011
  19. Bessueille L., Kawtharany L., Quillard T., Goettsch C., Briolay A., Taraconat N., et al. Inhibition of alkaline phosphatase impairs dyslipidemia and protects mice from atherosclerosis. Transl. Res. 2023; 251: 2–13. https://doi.org/10.1016/j.trsl.2022.06.010
  20. Derradi R., Bolean M., Simão A.M.S., Caseli L., Millán J.L., Bottini M., et al. Cholesterol regulates the incorporation and catalytic activity of tissue-nonspecific alkaline phosphatase in DPPC monolayers. Langmuir. 2019; 35(47): 15232–41. https://doi.org/10.1021/acs.langmuir.9b02590
  21. Cui S., Li W., Lv X., Wang P., Gao Y., Huang G. Folic acid supplementation delays atherosclerotic lesion development by modulating MCP1 and VEGF DNA methylation levels in vivo and in vitro. Int. J. Mol. Sci. 2017; 18(5): 990. https://doi.org/10.3390/ijms18050990
  22. Li G., Wu X.W., Lu W.H., Ai R., Chen F., Tang Z.Z. Effect of atorvastatin on the expression of gamma-glutamyl transferase in aortic atherosclerotic plaques of apolipoprotein E-knockout mice. BMC Cardiovasc. Disord. 2014; 14: 145. https://doi.org/10.1186/1471-2261-14-145
  23. Иконникова К.А., Ерощенко Н.Н., Дроздов В.Н., Ших Е.В., Сереброва С.Ю. Дискуссионные возможности биохимических маркеров функции печени у пациентов с алкогольным циррозом печени. Медицинский совет. 2022; 16(7): 76–83. https://doi.org/10.21518/2079-701X-2022-16-7-76-83 https://elibrary.ru/oxixej

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © , 2025


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 37884 от 02.10.2009.