PSGL-1: a universal selectin ligand or a signaling molecule?

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Abstract

Interactions of intercellular adhesion molecules of the selectin family with glycoconjugates of cell membranes mediate the initial stage of the adhesion cascade, which recruits leukocytes, circulating in the bloodstream, to the sites of infection or damage. The formation of heterotypic cell aggregates between individual cells of hematopoietic and non-hematopoietic origin may be involved in processes, leading to inflammation, thrombosis and metastasis. A key protein, plays an important role in the binding of selectins, which serves as a ligand for all three selectins, dimeric glycoprotein, P-selectin glycoprotein ligand — PSGL-1. PSGL-1 combines signals activating various biochemical pathways during binding and rolling of leukocytes. The integration of these signals leads to activation of leukocytes, integrin-mediated arrest, restructuring of the cytoskeleton of interacting cells, polarization and subsequent diapedesis of leukocytes into surrounding tissues. The multilevel effect of PSGL-1 on cellular traffic in the physiological and inflammatory states is largely determined by posttranslational modifications, among which an important place is given to specific O- and N-glycosylation and sulfation. In this review, we discuss modifications of PSGL-1 associated with the initiation of biochemical pathways, as well as its interactions, which make it possible to classify this molecule as signaling, paying special attention to the mechanisms leading to pathology, including cardiovascular.

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About the authors

N. V. Korotkova

Ryazan State Medical University

Author for correspondence.
Email: fnv8@yandex.ru
Russian Federation, Ryazan

R. E. Kalinin

Ryazan State Medical University

Email: fnv8@yandex.ru
Russian Federation, Ryazan

I. A. Suchkov

Ryazan State Medical University

Email: fnv8@yandex.ru
Russian Federation, Ryazan

N. D. Mzhavanadze

Ryazan State Medical University

Email: fnv8@yandex.ru
Russian Federation, Ryazan

L. V. Nikiforova

Ryazan State Medical University

Email: fnv8@yandex.ru
Russian Federation, Ryazan

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