Marine fungi: in search of new antibacterial drugs

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Abstract

The review deals with studies of antibacterial secondary metabolites of marine micromycete fungi as an element of a modern strategy for the search for new antibiotics. More than half of the drugs currently used in practice have been isolated from bacteria (Bacteria) and actinomycetes (Actinomycetes), however, the first antimicrobial compounds were isolated from mycelial fungi (Ascomycetes), and it is obvious that their potential has not been exhausted. Marine fungi occupy a separate niche due to the peculiarities of their habitats, which also affect their production of low molecular weight compounds. This paper provides information on the secondary metabolites of marine fungi acting against those bacterial targets aimed by the modern search for new antibiotics and discusses a strategy for investigating the antibacterial activity of marine fungal metabolites.

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About the authors

E. A. Yurchenko

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences

Author for correspondence.
Email: eyurch@piboc.dvo.ru
Russian Federation, Vladivostok

E. A. Chingizova

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences

Email: eyurch@piboc.dvo.ru
Russian Federation, Vladivostok

D. L. Aminin

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences

Email: eyurch@piboc.dvo.ru
Russian Federation, Vladivostok

A. N. Yurchenko

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences

Email: eyurch@piboc.dvo.ru
Russian Federation, Vladivostok

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Supplementary files

Supplementary Files
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2. Fig. 1. Structure of mycophenolic acid.

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3. Fig. 2. Structures of β-lactam metabolites of fungi.

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4. Fig. 3. Structures of peptide metabolites of marine fungi.

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5. Fig. 4. Structures of triterpene metabolites of marine fungi.

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6. Fig. 5. Structures of harzianic acid and some fungal 6/6/5-tricyclic polyketides.

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7. Fig. 6. Structures of secondary metabolites of marine fungi - inhibitors of nucleic acid synthesis in bacteria.

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8. Fig. 7. Structures of secondary metabolites of marine fungi – inhibitors of bacterial DNA primases.

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9. Fig. 8. Structures of fungal metabolites - antagonists of the Agr-system of Staphylococcus aureus.

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10. Fig. 9. Structures of secondary metabolites of marine fungi - inhibitors of sortase A.

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11. Fig. 10. Structure of flavuside B.

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12. Fig. 11. Structures of secondary metabolites of marine fungi – inhibitors of the QS system of gram-negative bacteria.

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13. Fig. 12. Structures of antibacterial low-molecular compounds obtained by co-cultivation of marine fungi with other microorganisms.

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