Purinergic modulation in the developing rat hippocampus

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Дәйексөз келтіру

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Рұқсат жабық Тек жазылушылар үшін

Аннотация

Even during early postnatal development, rhythmic electrical activity emerges across multiple regions of the nervous system, particularly in the hippocampus. Within this structure, such activity takes the form of giant depolarizing potentials (GDPs) — synchronized network events crucial for neuronal maturation and the establishment of synaptic connectivity. The generation and propagation of GDPs are regulated by multiple mechanisms, among which the purinergic system (involving ATP and adenosine), studied by our team, holds particular significance. Our research has demonstrated that during GDPs, ATP is released into the extracellular space and subsequently hydrolyzed to adenosine. Both ATP and adenosine can modulate the activity of neurons and glial cells in newborns through various types of purinergic receptors. This review synthesizes current data on the diverse effects of purinergic modulation in the neonatal hippocampus, the phenomenon of bidirectional purinergic signaling, and the expression and functional roles of all purinoceptor subtypes in the postnatal period. Special attention is given to the physiological role of purinergic modulation in the developing hippocampus.

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Рұқсат жабық

Авторлар туралы

V. Safiulina

Institute of Physiology in Komi Federal Research Center of the Scientific Center of the Ural Branch of the Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: Victoria.Safiulina@gmail.com
Ресей, Syktyvkar

Әдебиет тізімі

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2. Fig. 1. Scheme of the generally accepted classification of purinoceptors. Designations and abbreviations: P1 — group P1 purinergic (adenosine) receptors; A1 — adenosine receptors of subgroup A1; A2a — adenosine receptors of subgroup A2a; A2b — adenosine receptors of subgroup A2b; A3 — adenosine receptors of subgroup A3; P2 — group P2 purinergic receptors; P2X — subgroup of ionotropic purinergic receptors (types 1–7); P2Y — subgroup of metabotropic purinergic receptors (types 1–14).

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