Correlation between the indices of pro — and antioxidant activity in workers of the northern region with different levels of the anthropogenic load
- Authors: Korchina T.Y.1, Korchin V.I.1
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Affiliations:
- Ugra Khanty-Mansiysk State Medical Academy
- Issue: Vol 97, No 9 (2018)
- Pages: 831-834
- Section: OCCUPATIONAL HYGIENE
- Published: 20.10.2020
- URL: https://edgccjournal.org/0016-9900/article/view/640431
- DOI: https://doi.org/10.47470/0016-9900-2018-97-9-831-834
- ID: 640431
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Abstract
The biosubstrates of 170 adults of the Khanty-Mansiysk Autonomous Okrug were studied: 88 donors and 82 drivers and workers of the gas station. The average age amounted to 31.5 ± 7.4 years. Using commercial kits in the blood, the pro-oxidant (lipid hydroperoxide, Gpl, TBA-active products,TBA-AP) and antioxidant (total antioxidant activity, OAA, thiol-TC) system were determined. In hair, the concentration of toxic chemical elements (Pb, Cd), and also Se, Zn, Ca, possessing antioxidant activity was determined by the methods of AEM-ICP and MS-ICP. A significant excess of LPO values in the blood and toxic chemical elements in the hair was observed against the background of a decrease in the activity of antioxidant protection system indices in the group of drivers and workers at the gas station (p <0.001-0.026). The statistically significant direct relationships between Se, Zn, Ca on the one hand and OAA, TC, on the other (p = 0.0005-0.043) and reverse with Gpl and TBA-AP (p = 0.007-0.038) on the background of direct correlation Pb, Cd with Gpl, TBA-AP (p = 0.007-0.018) and reverse with OAA, TS, Se, Zn, Ca (p = 0.0005-0.020). This indicates the possibility of correction of the reserves of the antioxidant system with the help of vitamin-mineral complexes containing these micronutrients and enriched food products.
About the authors
T. Ya. Korchina
Ugra Khanty-Mansiysk State Medical Academy
Author for correspondence.
Email: t.korchina@mail.ru
MD, Ph.D., DSci., professor, Department of medical and biologic chemistry of the «Khanty-Mansiysk State Medical Academy», Khanty-Mansiysk, 628011, Russian Federation.
e-mail: t.korchina@mail.ru
Russian FederationV. I. Korchin
Ugra Khanty-Mansiysk State Medical Academy
Email: noemail@neicon.ru
Russian Federation
References
- Fateeva N.M. Human adaptation to extreme conditions of the far North. Mat. XXIII Congress of Physiology. society. I. P. Pavlov, 18-22 September 2017, Voronezh: 476-7.
- Hasnulin V.I., Hasnulin P.V. Modern understanding of the formation mechanisms of the Northern stress in humans at high latitudes Human Ecology. 2012; 1: 3-11.
- Sazontova T.G., Arkhipenko Yu.V. The value of the balance of Pro-oxidants and antioxidants – equivalent participants of metabolism. Pathologic physiology and experimental therapy. 2007; 3: 2-18.
- Tregubova I.A., Kosolapov V.A., Spasov A.A. Antioxidants: current state and prospects Uspekhi fiziologicheskikh nauk. 2012; 1: 75-94.
- Podunova L.G., Skachkov V.B., Skalny A.V., Demidov V.A., Skalnaya M.G., Serebryansky E.P., Grabeklys A.R., Kuznetsov V.V., Maymulov V.G., Limin B.V. Method for determination of microelements in diagnosed substrates by atomic spectrometry with inductively coupled argon plasma: method. recommendations. M., 2007c.
- Skalʼny A.V. Reference values for the concentration of chemical elements in hair obtained by the ISP-AES method (ANO CBM). Micronutrients in medicine. 2003; 4 (1): 55-6.
- Korchina T.Ya., Korchin V.I. Comparative characteristics of intoxication with lead and cadmium of the population of the Khanty-Mansiysk Autonomous Okrug. Hygiene and Sanitation. 2011; 3: 8-10.
- Michlska-Mosiej M. Socha K., Soroczynska J., Karpinska E., Lazarczyk B., borawska M.H. Selenium, Zink, Copper, and Total Antioxidant Status in the Serum of Patients with Chronic Tonsillitis Biological trace element research. 2016: 1-5.
- Skalʼny A.V., Sul’dina A.V., Ivanova N.A., Sambulova A.A., Lipina M.V. Development of means of treatment and prevention of mineral deficient states of zinc, copper, manganese, chromium and cobalt. Vestnik OSU 2011; 15 (134): 123-6.
- Karpukhina O.V., Gumargalieva K.Z., Inozemtsev A.N. Features of antioxidant regulation in the model of oxidative stress. Mat. 23rd Congress of Physiol. society them. I.P. Pavlova, September 18-22, 2017, Voronezh: 396-7.
- Zhuravleva E.A., Kamenskaya E.N., Bulina E.A., Sosnitskaya E.V., Kirpich I.A., Chumakova G.N. Role of zinc and copper in the micronutrient status of the newborn Human Ecology. 2007; 1: 23-8.
- Rebrov V.G., Gromova O.A. Vitamins, macro and microelements. Training programs of the RCC of the UNESCO Institute for Microelements. GEOTAR-Media, 2008.
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