Synthesis of bicyclo[2.2.1]heptane derivatives via one-pot three-component coupling of norbornene with aryl halide and arylacetylene using “ligand-free” pd catalytic systems

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Abstract

The results of Pd-catalyzed difunctionalization of norbornene via one-pot three-component coupling of norbornene, aryl halide and arylacetylene with new C(sp3)−C(sp2)/C(sp3) −C(sp) bond formation are presented. The convenience of the proposed approach compared to other methods is the use of a simple and accessible “ligand-free” catalytic system based on palladium salts and an inorganic base to obtain valuable bicyclo[2.2.1]heptane derivatives.

About the authors

E. V. Larina

Irkutsk State University, Chemical Department

ul. K. Marksa 1, Irkutsk, 664003 Russia

N. A. Lagoda

Irkutsk State University, Chemical Department

ul. K. Marksa 1, Irkutsk, 664003 Russia

A. A. Kurokhtina

Irkutsk State University, Chemical Department

ul. K. Marksa 1, Irkutsk, 664003 Russia

A. F. Schmidt

Irkutsk State University, Chemical Department

Email: aschmidt@chem.isu.ru
ul. K. Marksa 1, Irkutsk, 664003 Russia

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